Hi Paige,
Milk Thistle works differently than St. John’s Wort (different effects on different metabolic pathways in the liver). St. John’s wort is likely to be contraindicated for Lisdexamfetamine, where as Milk Thistle seems to have a hepatorestorative action more than a speeding up of specific clearance routes. It seems that milk thistle is safe to take and would be likely to support the liver in this case. Saying this however, it is wise to track any changes in symptoms and have regular testing to be clear on this.
With warmth,
Benna